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On 1 September 2005, in response to the disaster of Hurricane Katrina, Truman set sail for the devastated U.S. Gulf Coast. She arrived in the Gulf of Mexico on 4 September and served as the flagship for the Naval task force. While the ship's strike group (Carrier Strike Group 10) commander, Rear Adm. Joseph Kilkenny, was appointed deputy commander of Joint Task Force (JTF) Gulf Coast (also known as JTF Katrina & Rita), the ship remained anchored in the gulf and provided fresh desalinated water for the relief effort via helicopter (the actual command hub for the JTF was USS Iwo Jima). The carrier also provided support to JRB New Orleans in the form of aviation boatswain's mates and cooks to keep that station in operation.Harry S. Truman returned to home port in October 2005 after five weeks of relief efforts.