Cintron, Jose, NCCS

In 2004, Anzio participated at the annual Fleet Week in New York City. In January 2007, the warship was sent to the coast ofSomalia to conduct antiterrorist operations as part of the USSDwight D. Eisenhower task force.

On 16 February 2007, Anzio was awarded the 2006 Battle "E"award

The Anzio was anchored and a participant for 'Windjammer Days' inBoothbay Harbor, Maine, 25–26 June 2008.

Anzio has served as the flagship of the horn of Africa international anti-piracy Combined Task Force 151.

On October 15, 2009 a team from the cruiser working with U.S. Coast Guard personnel from Maritime Safety and Security Team 91104 seized a skiff carrying an estimated 4 tonsof hashish worth an estimated $28 million about 170 nautical miles (310 km) southwest of Salalah, Oman.The boarding team destroyed the drugs by dumping them into the ocean and released the skiff's crew 

• The cruiser USS Anzio was part of the aerial battle overWashington D.C. in the game series Ace Combat: Assault Horizon.
• USS Anzio appeared in Tom Clancy's Executive Orders as part of a task force escorting transport ships to Saudi Arabia.